PIK3CA Y606C
Gene Variant Detail

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Gene PIK3CA
Variant Y606C
Impact List missense
Protein Effect no effect
Gene Variant Descriptions PIK3CA Y606C lies within the PIK helical domain of the Pik3ca protein (UniProt.org). Y606C results similar levels of cell proliferation, migration, and phosphorylation of Akt to wild-type Pik3ca and is not transforming in culture (PMID: 34779417).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA Y606C

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Transcript NM_006218.4
gDNA chr3:g.179219641A>G
cDNA c.1817A>G
Protein p.Y606C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894.2 chr3:g.179219641A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179219641A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179219641A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179219641A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179219641A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References