Gene Variant Detail

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Gene PIK3CA
Variant W328S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA W328S does not lie within any known functional domains of the Pik3ca protein (UniProt.org). W328S results in increased levels of cell proliferation but leads to levels of cell migration and phosphorylation of Akt similar to wild-type Pik3ca and is not transforming in culture (PMID: 34779417), and therefore, its effect on Pik3ca protein function is unknown.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon5 PIK3CA W328S

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Transcript NM_006218.4
gDNA chr3:g.179203713G>C
cDNA c.983G>C
Protein p.W328S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.5 chr3:g.179203713G>C c.983G>C p.W328S RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179203713G>C c.983G>C p.W328S RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179203713G>C c.983G>C p.W328S RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179203713G>C c.983G>C p.W328S RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179203713G>C c.983G>C p.W328S RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References