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Gene | ROS1 |
Variant | K298* |
Impact List | nonsense |
Protein Effect | loss of function - predicted |
Gene Variant Descriptions | ROS1 K298* results in a premature truncation of the Ros1 protein at amino acid 298 of 2347 (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), K298* is predicted to lead to a loss of Ros1 protein function. |
Associated Drug Resistance | |
Category Variants Paths |
ROS1 mutant ROS1 inact mut ROS1 K298* |
Transcript | NM_002944.3 |
gDNA | chr6:g.117394703T>A |
cDNA | c.892A>T |
Protein | p.K298* |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |