Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene ROS1
Variant P1020fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions ROS1 P1020fs results in a change in the amino acid sequence of the Ros1 protein beginning at aa 1020 of 2347, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), P1020fs is predicted to lead to a loss of Ros1 protein function.
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 inact mut ROS1 P1020fs

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_002944.3
gDNA chr6:g.(117365120_117365121)
cDNA c.(3058_3057)
Protein p.P1020fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944 chr6:g.(117365120_117365121) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536049.2 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536049.3 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536057 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536049 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
NM_002944.2 chr6:g.(117365120_117365121) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
NM_002944.3 chr6:g.(117365120_117365121) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536058.3 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536058 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536054 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536055.2 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536057.3 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536056 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536055 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536057.4 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536055.3 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536054.2 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536054.3 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536056.2 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536058.2 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536056.3 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References