Gene Variant Detail

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Gene ROS1
Variant P1020fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions ROS1 P1020fs results in a change in the amino acid sequence of the Ros1 protein beginning at aa 1020 of 2347, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), P1020fs is predicted to lead to a loss of Ros1 protein function.
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 inact mut ROS1 P1020fs

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Transcript NM_002944.3
gDNA chr6:g.(117365120_117365121)
cDNA c.(3058_3057)
Protein p.P1020fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011536049.2 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536056.3 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536055.2 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536057 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536056.2 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536054 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536058.3 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536058.2 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536049 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536054.3 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536055.3 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536055 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536049.3 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536054.2 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
NM_002944 chr6:g.(117365120_117365121) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536057.3 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536056 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
NM_002944.2 chr6:g.(117365120_117365121) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536057.4 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
NM_002944.3 chr6:g.(117365120_117365121) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38
XM_011536058 chr6:g.(117365150_117365151) c.(3058_3057) p.P1020fs RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References