ROS1 P1539S
Gene Variant Detail

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Gene ROS1
Variant P1539S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 P1539S lies within fibronectin type-III domain 6 of the Ros1 protein (UniProt.org). P1539S has been identified in sequencing studies (PMID: 28153863), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Aug 2025).
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 P1539S

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Transcript NM_002944.3
gDNA chr6:g.117342454G>A
cDNA c.4615C>T
Protein p.P1539S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378902.1 chr6:g.117342436G>A c.4615C>T p.P1539S RefSeq GRCh38/hg38
NM_002944 chr6:g.117342454G>A c.4615C>T p.P1539S RefSeq GRCh38/hg38
XM_011536053 chr6:g.117341543G>A c.4615C>T p.P1539S RefSeq GRCh38/hg38
XM_006715548.4 chr6:g.117342439G>A c.4615C>T p.P1539S RefSeq GRCh38/hg38
XM_011536053.3 chr6:g.117341543G>A c.4615C>T p.P1539S RefSeq GRCh38/hg38
XM_006715548.5 chr6:g.117342439G>A c.4615C>T p.P1539S RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117342454G>A c.4615C>T p.P1539S RefSeq GRCh38/hg38
XM_011536053.2 chr6:g.117341543G>A c.4615C>T p.P1539S RefSeq GRCh38/hg38
XM_006715548 chr6:g.117342439G>A c.4615C>T p.P1539S RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117342454G>A c.4615C>T p.P1539S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries