BTK T474A
Gene Variant Detail

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Gene BTK
Variant T474A
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions BTK T474A lies within the protein kinase domain of the Btk protein (UniProt.org). T474A confers a loss of function to Btk as demonstrated by reduced kinase activity in cell culture (PMID: 33526860, PMID: 21138328).
Associated Drug Resistance
Category Variants Paths

BTK mutant BTK inact mut BTK T474A

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Transcript NM_000061.3
gDNA chrX:g.101356198T>C
cDNA c.1420A>G
Protein p.T474A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000061.3 chrX:g.101356198T>C c.1420A>G p.T474A RefSeq GRCh38/hg38
NM_000061.2 chrX:g.101356198T>C c.1420A>G p.T474A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BTK T474A Advanced Solid Tumor predicted - sensitive Ibrutinib Preclinical - Biochemical Actionable In a preclinical study, treatment with Imbruvica (ibrutinib) resulted in reduced Btk activity in cell lines expressing BTK T474A in culture (PMID: 33526860). 33526860
BTK T474A Advanced Solid Tumor predicted - sensitive Fenebrutinib Preclinical - Biochemical Actionable In a preclinical study, treatment with Fenebrutinib (GDC-0853) resulted in reduced Btk activity in a cell line expressing BTK T474A in culture (PMID: 33526860). 33526860