STK11 H202R
Gene Variant Detail

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Gene STK11
Variant H202R
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions STK11 H202R lies within the protein kinase domain of the Stk11 protein (UniProt.org). H202R demonstrates autophosphorylation similar to wild-type Stk11 in an in vitro assay, but results in decreased Stk11-dependent Tp53-mediated transcriptional activation in a reporter assay (PMID: 34849607, PMID: 39934475), and therefore, is predicted to lead to a loss of Stk11 protein function.
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 inact mut STK11 H202R

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Transcript NM_000455.5
gDNA chr19:g.1220588A>G
cDNA c.605A>G
Protein p.H202R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000455.4 chr19:g.1220588A>G c.605A>G p.H202R RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.1220588A>G c.605A>G p.H202R RefSeq GRCh38/hg38
XM_005259618.3 chr19:g.1220588A>G c.605A>G p.H202R RefSeq GRCh38/hg38
NM_000455.5 chr19:g.1220588A>G c.605A>G p.H202R RefSeq GRCh38/hg38
NM_001407255.1 chr19:g.1220588A>G c.605A>G p.H202R RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References