STK11 A417S
Gene Variant Detail

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Gene STK11
Variant A417S
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions STK11 A417S lies within the C-terminal domain of the Stk11 protein (PMID: 23612973). A417S results in kinase activity similar to wild-type Stk11 in an in vitro assay and Stk11-dependent Tp53-mediated transcriptional activity similar to wild-type in a reporter assay (PMID: 34849607, PMID: 39934475), and therefore, is predicted to have no effect on Stk11 protein function.
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 A417S

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Transcript NM_000455.5
gDNA chr19:g.1226594G>T
cDNA c.1249G>T
Protein p.A417S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000455.4 chr19:g.1226594G>T c.1249G>T p.A417S RefSeq GRCh38/hg38
NM_000455.5 chr19:g.1226594G>T c.1249G>T p.A417S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries