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| Gene | FGFR2 |
| Variant | T370_A371delinsS |
| Impact List | indel |
| Protein Effect | unknown |
| Gene Variant Descriptions | FGFR2 T370_A371delinsS results in a deletion of a threonine (T) and an alanine (A) from aa 370 to aa 371 within the extracellular domain of the Fgfr2 protein, combined with the insertion of a serine (S) at the same site (UniProt.org). T370_A371delinsS has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Mar 2026). |
| Associated Drug Resistance | |
| Category Variants Paths |
FGFR2 mutant FGFR2 T370_A371delinsS |
| Transcript | NM_000141.5 |
| gDNA | chr10:g.121515291_121515296delinsGCT |
| cDNA | c.1108_1113delinsAGC |
| Protein | p.T370_A371delinsS |
| Source Database | RefSeq |
| Genome Build | GRCh38/hg38 |
| Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
|---|---|---|---|---|---|
| NM_000141.5 | chr10:g.121515291_121515296delinsGCT | c.1108_1113delinsAGC | p.T370_A371delinsS | RefSeq | GRCh38/hg38 |
| NM_001320658.1 | chr10:g.121515291_121515296delinsGCT | c.1108_1113delinsAGC | p.T370_A371delinsS | RefSeq | GRCh38/hg38 |
| NM_000141.4 | chr10:g.121515291_121515296delinsGCT | c.1108_1113delinsAGC | p.T370_A371delinsS | RefSeq | GRCh38/hg38 |
| NM_001320658.2 | chr10:g.121515291_121515296delinsGCT | c.1108_1113delinsAGC | p.T370_A371delinsS | RefSeq | GRCh38/hg38 |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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