POLE R34L
Gene Variant Detail

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Gene POLE
Variant R34L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions POLE R34L does not lie within any known functional domains of the Pole protein (UniProt.org). R34L has been identified in the scientific literature (PMID: 34875656), but has not been biochemically characterized and therefore, its effect on Pole protein function is unknown (PubMed, Aug 2025).
Associated Drug Resistance
Category Variants Paths

POLE mutant POLE R34L

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Transcript NM_006231.4
gDNA chr12:g.132681241C>A
cDNA c.101G>T
Protein p.R34L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011534795.4 chr12:g.132681241C>A c.101G>T p.R34L RefSeq GRCh38/hg38
NM_006231.4 chr12:g.132681241C>A c.101G>T p.R34L RefSeq GRCh38/hg38
XM_047429018.1 chr12:g.132681241C>A c.101G>T p.R34L RefSeq GRCh38/hg38
NM_006231.3 chr12:g.132681241C>A c.101G>T p.R34L RefSeq GRCh38/hg38
XM_011534799.2 chr12:g.132681241C>A c.101G>T p.R34L RefSeq GRCh38/hg38
XM_011534795.3 chr12:g.132681241C>A c.101G>T p.R34L RefSeq GRCh38/hg38
XM_011534799.3 chr12:g.132681241C>A c.101G>T p.R34L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References