KIT Y870*
Gene Variant Detail

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Gene KIT
Variant Y870*
Impact List nonsense
Protein Effect unknown
Gene Variant Descriptions KIT Y870* results in a premature truncation of the Kit protein at amino acid 870 of 976 (UniProt.org). Y870* has been identified in sequencing studies (PMID: 35041493), but has not been biochemically characterized and therefore, its effect on Kit protein function is unknown (PubMed, Jul 2025).
Associated Drug Resistance
Category Variants Paths

KIT mutant KIT Y870*

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Transcript NM_000222.3
gDNA chr4:g.54736734T>A
cDNA c.2610T>A
Protein p.Y870*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000222.2 chr4:g.54736734T>A c.2610T>A p.Y870* RefSeq GRCh38/hg38
NM_000222.3 chr4:g.54736734T>A c.2610T>A p.Y870* RefSeq GRCh38/hg38
XM_005265741.1 chr4:g.54736734T>A c.2610T>A p.Y870* RefSeq GRCh38/hg38
NM_001385290.1 chr4:g.54736734T>A c.2610T>A p.Y870* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References