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Gene PTEN
Variant Y65S
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions PTEN Y65S lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). Y65S confers a loss of function on Pten as demonstrated by altered cell morphology and cytoskeletal organization, decreased ability to suppress proliferation and migration, and increased phosphorylation of Akt in cultured cells, and resistance to apoptotic induction in one of two assays (PMID: 34943931).
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN Y65S

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Transcript NM_000314.8
gDNA chr10:g.87925542A>C
cDNA c.194A>C
Protein p.Y65S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.6 chr10:g.87925542A>C c.194A>C p.Y65S RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87925542A>C c.194A>C p.Y65S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References