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Gene PIK3CA
Variant I459_T462del
Impact List deletion
Protein Effect gain of function - predicted
Gene Variant Descriptions PIK3CA I459_T462del results in the deletion of four amino acids in the C2 PI3K-type domain of the Pik3ca protein from amino acids 459 to 462 (UniProt.org). PIK3CA I459_T462del results in increased phosphorylation of Akt, Erk, P70S6K, and S6 in culture (PMID: 35012940), and therefore, is predicted to lead to a gain of Pik3ca protein function.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA I459_T462del

PIK3CA mutant PIK3CA exon8 PIK3CA I459_T462del

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Transcript NM_006218.4
gDNA chr3:g.179210309_179210320del12
cDNA c.1375_1386del12
Protein p.I459_T462delIGVT
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.4 chr3:g.179210309_179210320del12 c.1375_1386del12 p.I459_T462delIGVT RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179210309_179210320del12 c.1375_1386del12 p.I459_T462del RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210309_179210320del12 c.1375_1386del12 p.I459_T462delIGVT RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179210309_179210320del12 c.1375_1386del12 p.I459_T462del RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179210309_179210320del12 c.1375_1386del12 p.I459_T462del RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
PIK3CA I459_T462del gain of function - predicted Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor mTOR Inhibitor mTORC1 Inhibitor mTORC2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor