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Gene CSF3R
Variant V406fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions CSF3R V406fs results in a change in the amino acid sequence of the Csf3r protein beginning at aa 406 of 836, likely resulting in premature truncation of the functional protein (UniProt.org). Due to loss of the transmembrane and cytoplasmic domains (UniProt.org), V406fs is predicted to lead to a loss of Csf3r protein function.
Associated Drug Resistance
Category Variants Paths

CSF3R mutant CSF3R inact mut CSF3R V406fs

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Transcript NM_000760.4
gDNA chr1:g.(36471502_36471503)
cDNA c.(1216_1215)
Protein p.V406fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047446753.1 chr1:g.(36471502_36471503) c.(1216_1215) p.V406fs RefSeq GRCh38/hg38
NM_156039.3 chr1:g.(36471502_36471503) c.(1216_1215) p.V406fs RefSeq GRCh38/hg38
XM_017000370.1 chr1:g.(36471502_36471503) c.(1216_1215) p.V406fs RefSeq GRCh38/hg38
NM_000760.3 chr1:g.(36471502_36471503) c.(1216_1215) p.V406fs RefSeq GRCh38/hg38
NM_156039.3 chr1:g.(36471502_36471503) c.(1216_1215) p.V406fs RefSeq GRCh38/hg38
XM_005270493.1 chr1:g.(36471502_36471503) c.(1216_1215) p.V406fs RefSeq GRCh38/hg38
NM_172313.2 chr1:g.(36471502_36471503) c.(1216_1215) p.V406fs RefSeq GRCh38/hg38
XM_005270493.1 chr1:g.(36471502_36471503) c.(1216_1215) p.V406fs RefSeq GRCh38/hg38
NM_172313.3 chr1:g.(36471502_36471503) c.(1216_1215) p.V406fs RefSeq GRCh38/hg38
XM_011540749.1 chr1:g.(36471502_36471503) c.(1216_1215) p.V406fs RefSeq GRCh38/hg38
XM_011540749.1 chr1:g.(36471502_36471503) c.(1216_1215) p.V406fs RefSeq GRCh38/hg38
XM_011540748.3 chr1:g.(36471502_36471503) c.(1216_1215) p.V406fs RefSeq GRCh38/hg38
NM_000760.4 chr1:g.(36471502_36471503) c.(1216_1215) p.V406fs RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References