PTEN S227F
Gene Variant Detail

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Gene PTEN
Variant S227F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PTEN S227F lies within the C2 tensin-type domain of the Pten protein (UniProt.org). S227F results in loss of phosphatase activity in an in vitro assay in one study (PMID: 10866302), but phosphatase activity similar to wild-type in another study (PMID: 11156408) and inhibition of anchorage-independent growth similar to wild-type (PMID: 11156408), and therefore, its effect on Pten protein function is unknown.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN S227F

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Transcript NM_000314.8
gDNA chr10:g.87957898C>T
cDNA c.680C>T
Protein p.S227F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.8 chr10:g.87957898C>T c.680C>T p.S227F RefSeq GRCh38/hg38
NM_000314 chr10:g.87957898C>T c.680C>T p.S227F RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87957898C>T c.680C>T p.S227F RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries