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Gene ROS1
Variant A1924_I1934del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions ROS1 A1924_I1934del results in the deletion of 11 amino acids in the cytoplasmic domain of the Ros1 protein from amino acids 1924 to 1934 (UniProt.org). A1924_I1934del has been identified in the scientific literature (PMID: 34907086), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 A1924_I1934del

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Transcript NM_002944.3
gDNA chr6:g.117320007_117321267del1261
cDNA c.5771_5803del1261
Protein p.A1924_I1934del11
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017011172.2 chr6:g.117319967_117319999del33 c.5771_5803del33 p.L1924_L1934del11 RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117320007_117321267del1261 c.5771_5803del1261 p.A1924_I1934del11 RefSeq GRCh38/hg38
XM_011536051.3 chr6:g.117320009_117321269del1261 c.5770_5802del1261 p.Y1924_E1934del11 RefSeq GRCh38/hg38
XM_017011173.2 chr6:g.117319965_117319997del33 c.5771_5803del33 p.P1924_R1934del11 RefSeq GRCh38/hg38
NM_001378891.1 chr6:g.117319996_117320028del33 c.5770_5802del33 p.L1924_P1934del11 RefSeq GRCh38/hg38
XM_011536050.3 chr6:g.117321261_117321293del33 c.5770_5802del33 p.G1924_I1934del11 RefSeq GRCh38/hg38
XM_006715548.5 chr6:g.117319991_117320023del33 c.5770_5802del33 p.P1924_A1934del11 RefSeq GRCh38/hg38
XM_011536053.3 chr6:g.117318247_117319894del1648 c.5771_5803del1648 p.S1924_L1934del11 RefSeq GRCh38/hg38
NM_001378902.1 chr6:g.117319988_117320020del33 c.5770_5802del33 p.T1924_F1934del11 RefSeq GRCh38/hg38
XM_011536054.3 chr6:g.117321267_117321299del33 c.5770_5802del33 p.A1924_A1934del11 RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117320007_117321267del1261 c.5771_5803del1261 p.A1924_I1934del RefSeq GRCh38/hg38
XM_011536049.3 chr6:g.117321267_117321299del33 c.5770_5802del33 p.A1924_A1934del11 RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References