Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Gene | ROS1 |
Variant | A1924_I1934del |
Impact List | deletion |
Protein Effect | unknown |
Gene Variant Descriptions | ROS1 A1924_I1934del results in the deletion of 11 amino acids in the cytoplasmic domain of the Ros1 protein from amino acids 1924 to 1934 (UniProt.org). A1924_I1934del has been identified in the scientific literature (PMID: 34907086), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Mar 2024). |
Associated Drug Resistance | |
Category Variants Paths |
ROS1 mutant ROS1 A1924_I1934del |
Transcript | NM_002944.3 |
gDNA | chr6:g.117320007_117321267del1261 |
cDNA | c.5771_5803del1261 |
Protein | p.A1924_I1934del11 |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
XM_006715548.5 | chr6:g.117319991_117320023del33 | c.5770_5802del33 | p.P1924_A1934del11 | RefSeq | GRCh38/hg38 |
XM_017011172.2 | chr6:g.117319967_117319999del33 | c.5771_5803del33 | p.L1924_L1934del11 | RefSeq | GRCh38/hg38 |
XM_011536054.3 | chr6:g.117321267_117321299del33 | c.5770_5802del33 | p.A1924_A1934del11 | RefSeq | GRCh38/hg38 |
XM_011536050.3 | chr6:g.117321261_117321293del33 | c.5770_5802del33 | p.G1924_I1934del11 | RefSeq | GRCh38/hg38 |
XM_011536051.3 | chr6:g.117320009_117321269del1261 | c.5770_5802del1261 | p.Y1924_E1934del11 | RefSeq | GRCh38/hg38 |
NM_001378902.1 | chr6:g.117319988_117320020del33 | c.5770_5802del33 | p.T1924_F1934del11 | RefSeq | GRCh38/hg38 |
NM_001378891.1 | chr6:g.117319996_117320028del33 | c.5770_5802del33 | p.L1924_P1934del11 | RefSeq | GRCh38/hg38 |
XM_011536053.3 | chr6:g.117318247_117319894del1648 | c.5771_5803del1648 | p.S1924_L1934del11 | RefSeq | GRCh38/hg38 |
NM_002944.2 | chr6:g.117320007_117321267del1261 | c.5771_5803del1261 | p.A1924_I1934del | RefSeq | GRCh38/hg38 |
NM_002944.3 | chr6:g.117320007_117321267del1261 | c.5771_5803del1261 | p.A1924_I1934del11 | RefSeq | GRCh38/hg38 |
XM_011536049.3 | chr6:g.117321267_117321299del33 | c.5770_5802del33 | p.A1924_A1934del11 | RefSeq | GRCh38/hg38 |
XM_017011173.2 | chr6:g.117319965_117319997del33 | c.5771_5803del33 | p.P1924_R1934del11 | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|