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Gene ROS1
Variant K1980E
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions ROS1 K1980E lies within the protein kinase domain of the Ros1 protein (UniProt.org). K1980E results in loss of Ros1 protein function as demonstrated by decreased Ros1 phosphorylation, and failure to induce colony growth in culture or tumor formation in a mouse model (PMID: 37587872).
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 inact mut ROS1 K1980E

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Transcript NM_002944.3
gDNA chr6:g.117319870T>C
cDNA c.5938A>G
Protein p.K1980E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944.2 chr6:g.117319870T>C c.5938A>G p.K1980E RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117319870T>C c.5938A>G p.K1980E RefSeq GRCh38/hg38
NM_001378891.1 chr6:g.117318243T>C c.5938A>G p.K1980E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ROS1 K1980E loss of function