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Gene APC
Variant A1366V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions APC A1366V lies within the beta-catenin binding and downregulation region of the Apc protein (PMID: 14672538). A1366V has been identified in the scientific literature (PMID: 21901162), but has not been biochemically characterized and therefore, its effect on Apc protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

APC mutant APC A1366V

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Transcript NM_000038.6
gDNA chr5:g.112839691C>T
cDNA c.4097C>T
Protein p.A1366V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354902.1 chr5:g.112839964C>T c.4097C>T p.A1366V RefSeq GRCh38/hg38
NM_001354902.2 chr5:g.112839964C>T c.4097C>T p.A1366V RefSeq GRCh38/hg38
NM_001127510 chr5:g.112839691C>T c.4097C>T p.A1366V RefSeq GRCh38/hg38
NM_001354904.1 chr5:g.112840069C>T c.4097C>T p.A1366V RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112839691C>T c.4097C>T p.A1366V RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112839691C>T c.4097C>T p.A1366V RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112839691C>T c.4097C>T p.A1366V RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112839691C>T c.4097C>T p.A1366V RefSeq GRCh38/hg38
NM_000038 chr5:g.112839691C>T c.4097C>T p.A1366V RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112839691C>T c.4097C>T p.A1366V RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112839691C>T c.4097C>T p.A1366V RefSeq GRCh38/hg38
NM_001354904.2 chr5:g.112840069C>T c.4097C>T p.A1366V RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112839691C>T c.4097C>T p.A1366V RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References