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Gene PTEN
Variant K183Ifs*15
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions PTEN K183Ifs*15 indicates a shift in the reading frame starting at amino acid 183 and terminating 15 residues downstream causing a premature truncation of the 403 amino acid Pten protein (UniProt.org). K183Ifs*15 has not been characterized, however, due to the effects of other truncation mutations downstream of K183 (PMID: 10468583), is predicted to lead to a loss of Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN K183Ifs*15

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Transcript NM_000314.8
gDNA chr10:g.87952173_87952176delAGAA
cDNA c.548_551delAGAA
Protein p.K183Ifs*15
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.6 chr10:g.87952173_87952176delAGAA c.548_551delAGAA p.K183Ifs*15 RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87952173_87952176delAGAA c.548_551delAGAA p.K183Ifs*15 RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References