PTEN G251del
Gene Variant Detail

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Gene PTEN
Variant G251del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions PTEN G251del results in the deletion of an amino acid in the C2 tensin-type domain of the Pten protein at amino acid 251 (UniProt.org). G251del has been identified in the scientific literature (PMID: 35171658), but has not been biochemically characterized and therefore, its effect on Pten protein function is unknown (PubMed, Dec 2024).
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN G251del

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Transcript NM_000314.8
gDNA chr10:g.87957970_87957972delGTG
cDNA c.752_754delGTG
Protein p.G251delG
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001304717.5 chr10:g.87931068_87931070delACC c.751_753delACC p.T251delT RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87957970_87957972delGTG c.752_754delGTG p.G251del RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87957970_87957972delGTG c.752_754delGTG p.G251delG RefSeq GRCh38/hg38

Filtering

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  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References