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Gene TET2
Variant C1642Wfs*49
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TET2 C1642Wfs*49 indicates a shift in the reading frame starting at amino acid 1642 and terminating 49 residues downstream causing a premature truncation of the 2002 amino acid Tet2 protein (UniProt.org). C1642Wfs*49 has not been characterized however, due to the effects of other truncation mutations downstream of C1642 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
Associated Drug Resistance
Category Variants Paths

TET2 mutant TET2 inact mut TET2 C1642Wfs*49

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Transcript NM_001127208.3
gDNA chr4:g.(105275434_105275583)
cDNA c.(4924_5073)
Protein p.C1642Wfs*49
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_024454103.1 chr4:g.(105275434_105275583) c.(4924_5073) p.C1642Wfs*49 RefSeq GRCh38/hg38
XM_024454102.1 chr4:g.(105275434_105275583) c.(4924_5073) p.C1642Wfs*49 RefSeq GRCh38/hg38
XM_024454103.2 chr4:g.(105275434_105275583) c.(4924_5073) p.C1642Wfs*49 RefSeq GRCh38/hg38
NM_001127208.2 chr4:g.(105275434_105275583) c.(4924_5073) p.C1642Wfs*49 RefSeq GRCh38/hg38
XM_005263082.4 chr4:g.(105275434_105275583) c.(4924_5073) p.C1642Wfs*49 RefSeq GRCh38/hg38
XM_024454102.2 chr4:g.(105275434_105275583) c.(4924_5073) p.C1642Wfs*49 RefSeq GRCh38/hg38
NM_001127208.3 chr4:g.(105275434_105275583) c.(4924_5073) p.C1642Wfs*49 RefSeq GRCh38/hg38
XM_005263082.3 chr4:g.(105275434_105275583) c.(4924_5073) p.C1642Wfs*49 RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References