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Gene PTEN
Variant G132del
Impact List deletion
Protein Effect loss of function - predicted
Gene Variant Descriptions PTEN G132del results in the deletion of an amino acid within the phosphatase tensin-type domain of the Pten protein at amino acid 132 (UniProt.org). G132del results in reduced phosphatase activity in a yeast assay (PMID: 29706350), and therefore, is predicted to lead to a loss of Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN G132del

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Transcript NM_000314.8
gDNA chr10:g.87933154_87933156delGTG
cDNA c.395_397delGTG
Protein p.G132delG
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.6 chr10:g.87933154_87933156delGTG c.395_397delGTG p.G132del RefSeq GRCh38/hg38
NM_001304718.2 chr10:g.87961079_87961081delTAA c.396_398delTAA p.N132delN RefSeq GRCh38/hg38
NM_001304717.5 chr10:g.87864346_87864348delGGC c.396_398delGGC p.A133delA RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87933154_87933156delGTG c.395_397delGTG p.G132delG RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References