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Gene APC
Variant G1357fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC G1357fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1357 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). G1357fs has not been characterized, however, due to the effects of other truncation mutations downstream of G1357 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC G1357fs

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Transcript NM_000038.6
gDNA chr5:g.(112839662_112839663)
cDNA c.(4069_4068)
Protein p.G1357fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407449.1 chr5:g.(112839608_112839609) c.(4069_4068) p.G1357fs RefSeq GRCh38/hg38
NM_001407448.1 chr5:g.(112839608_112839609) c.(4069_4068) p.G1357fs RefSeq GRCh38/hg38
NM_001354901.1 chr5:g.(112839839_112839840) c.(4069_4068) p.G1357fs RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.(112839662_112839663) c.(4069_4068) p.G1357fs RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.(112839662_112839663) c.(4069_4068) p.G1357fs RefSeq GRCh38/hg38
NM_001407453.1 chr5:g.(112839839_112839840) c.(4069_4068) p.G1357fs RefSeq GRCh38/hg38
NM_001354901.2 chr5:g.(112839839_112839840) c.(4069_4068) p.G1357fs RefSeq GRCh38/hg38
NM_000038.5 chr5:g.(112839662_112839663) c.(4069_4068) p.G1357fs RefSeq GRCh38/hg38
NM_001407447.1 chr5:g.(112839608_112839609) c.(4069_4068) p.G1357fs RefSeq GRCh38/hg38
NM_001354896.2 chr5:g.(112839608_112839609) c.(4069_4068) p.G1357fs RefSeq GRCh38/hg38
NM_000038 chr5:g.(112839662_112839663) c.(4069_4068) p.G1357fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112839662_112839663) c.(4069_4068) p.G1357fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112839662_112839663) c.(4069_4068) p.G1357fs RefSeq GRCh38/hg38
NM_001127510 chr5:g.(112839662_112839663) c.(4069_4068) p.G1357fs RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.(112839662_112839663) c.(4069_4068) p.G1357fs RefSeq GRCh38/hg38
NM_001354896.1 chr5:g.(112839608_112839609) c.(4069_4068) p.G1357fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112839662_112839663) c.(4069_4068) p.G1357fs RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries