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CDKN2A A36V - Gene Variant Detail

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Gene CDKN2A
Variant A36V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions CDKN2A A36V lies within ANK repeat 1 of the Cdkn2a protein (UniProt.org). A36V results in decreased suppression of IL3-independent growth in BCR-ABL1-expressing cells in culture (PMID: 34369425), but has not been individually characterized and therefore, its effect on Cdkn2a protein function is unknown.
Associated Drug Resistance
Category Variants Paths

CDKN2A mutant CDKN2A A36V

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Transcript NM_000077.5
gDNA chr9:g.21974721G>A
cDNA c.107C>T
Protein p.A36V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011517676.2 chr9:g.21974721G>A c.107C>T p.A36V RefSeq GRCh38/hg38
NM_058197.4 chr9:g.21974721G>A c.107C>T p.A36V RefSeq GRCh38/hg38
NM_058195.4 chr9:g.21994225G>A c.107C>T p.A36V RefSeq GRCh38/hg38
XM_011517675.2 chr9:g.21974721G>A c.107C>T p.A36V RefSeq GRCh38/hg38
XM_011517676.3 chr9:g.21974721G>A c.107C>T p.A36V RefSeq GRCh38/hg38
NM_001195132.1 chr9:g.21974721G>A c.107C>T p.A36V RefSeq GRCh38/hg38
NM_000077.5 chr9:g.21974721G>A c.107C>T p.A36V RefSeq GRCh38/hg38
NM_058197.5 chr9:g.21974721G>A c.107C>T p.A36V RefSeq GRCh38/hg38
NM_001195132.2 chr9:g.21974721G>A c.107C>T p.A36V RefSeq GRCh38/hg38
NM_000077.4 chr9:g.21974721G>A c.107C>T p.A36V RefSeq GRCh38/hg38
XM_011517675.3 chr9:g.21974721G>A c.107C>T p.A36V RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References