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Gene PTEN
Variant P96del
Impact List deletion
Protein Effect loss of function - predicted
Gene Variant Descriptions PTEN P96del results in the deletion of an amino acid within the phosphatase tensin-type domain of the Pten protein at amino acid 96 (UniProt.org). P96del results in reduced phosphatase activity in a yeast assay (PMID: 29706350), and therefore, is predicted to lead to a loss of Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN P96del

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Transcript NM_000314.8
gDNA chr10:g.87933046_87933048delCAC
cDNA c.287_289delCAC
Protein p.P96delP
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.6 chr10:g.87933046_87933048delCAC c.287_289delCAC p.P96del RefSeq GRCh38/hg38
NM_001304718.2 chr10:g.87960969_87960971delGGA c.286_288delGGA p.G96delG RefSeq GRCh38/hg38
NM_001304717.5 chr10:g.87864241_87864243delCGC c.291_293delCGC p.A99delA RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87933046_87933048delCAC c.287_289delCAC p.P96delP RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
PTEN P96del loss of function - predicted Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor PI3K Inhibitor (Pan) PIK3CB inhibitor