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Gene TP53
Variant K382Nfs*96
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions TP53 K382Nfs*96 indicates a shift in the reading frame starting at amino acid 382 and terminating 96 residues downstream, resulting in premature truncation of the functional protein and extension of the 393 aa Tp53 protein length by 85 amino acids (UniProt.org). K382Nfs*96 has not been characterized in the scientific literature and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon11 TP53 K382Nfs*96

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Transcript NM_000546.6
gDNA chr17:g.7669650delT
cDNA c.1146delA
Protein p.K382Nfs*96
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126112.2 chr17:g.7669650delT c.1146delA p.K382Nfs*96 RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7669650delT c.1146delA p.K382Nfs*96 RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7669650delT c.1146delA p.K382Nfs*96 RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7669650delT c.1146delA p.K382Nfs*96 RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7669650delT c.1146delA p.K382Nfs*96 RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7669650delT c.1146delA p.K382Nfs*96 RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7669650delT c.1146delA p.K382Nfs*96 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References