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Gene PTEN
Variant S10del
Impact List deletion
Protein Effect loss of function - predicted
Gene Variant Descriptions PTEN S10del results in the deletion of an amino acid within the Pten protein at amino acid ten (UniProt.org). S10del results in reduced phosphatase activity in a yeast assay (PMID: 29706350), and therefore, is predicted to lead to a loss of Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN S10del

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Transcript NM_000314.8
gDNA chr10:g.87864499_87864501delCAG
cDNA c.30_32delCAG
Protein p.S10delS
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001304718.1 chr10:g.87952244_87952246delAGT c.28_30delAGT p.S10del RefSeq GRCh38/hg38
NM_001304718.2 chr10:g.87952244_87952246delAGT c.28_30delAGT p.S10delS RefSeq GRCh38/hg38
NM_001304717.5 chr10:g.87863982_87863984delGGC c.33_35delGGC p.A17delA RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87864499_87864501delCAG c.30_32delCAG p.S10del RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87864499_87864501delCAG c.30_32delCAG p.S10delS RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References