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Gene PTEN
Variant T160del
Impact List deletion
Protein Effect loss of function - predicted
Gene Variant Descriptions PTEN T160del results in the deletion of an amino acid within the phosphatase tensin-type domain of the Pten protein at amino acid 160 (UniProt.org). T160del results in reduced phosphatase activity in a yeast assay (PMID: 29706350), and therefore, is predicted to lead to a loss of Pten protein function
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN T160del

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Transcript NM_000314.8
gDNA chr10:g.87933238_87933240delCCA
cDNA c.479_481delCCA
Protein p.T160delT
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001304718.2 chr10:g.87965329_87965331delCCA c.478_480delCCA p.P160delP RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87933238_87933240delCCA c.479_481delCCA p.T160delT RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87933238_87933240delCCA c.479_481delCCA p.T160del RefSeq GRCh38/hg38
NM_001304717.5 chr10:g.87864428_87864430delCCA c.478_480delCCA p.P160delP RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References