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Gene PTEN
Variant T277del
Impact List deletion
Protein Effect loss of function - predicted
Gene Variant Descriptions PTEN T277del results in the deletion of an amino acid in the C2 tensin-type domain of the Pten protein at amino acid 277 (UniProt.org). T277del results in reduced phosphatase activity in a yeast assay (PMID: 29706350), and therefore, is predicted to lead to a loss of Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN T277del

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Transcript NM_000314.8
gDNA chr10:g.87960921_87960923delACA
cDNA c.829_831delACA
Protein p.T277delT
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.6 chr10:g.87960921_87960923delACA c.829_831delACA p.T277del RefSeq GRCh38/hg38
NM_001304717.5 chr10:g.87933070_87933072delTTT c.830_832delTTT p.F277delF RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87960921_87960923delACA c.829_831delACA p.T277delT RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References