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Gene APC
Variant M1431fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC M1431fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1431 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). M1431fs has not been characterized, however, due to the effects of other truncation mutations downstream of M1431 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC M1431fs

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Transcript NM_000038.6
gDNA chr5:g.(112839884_112839885)
cDNA c.(4291_4290)
Protein p.M1431fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000038.5 chr5:g.(112839884_112839885) c.(4291_4290) p.M1431fs RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.(112839884_112839885) c.(4291_4290) p.M1431fs RefSeq GRCh38/hg38
NM_001354896.2 chr5:g.(112839830_112839831) c.(4291_4290) p.M1431fs RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.(112839884_112839885) c.(4291_4290) p.M1431fs RefSeq GRCh38/hg38
NM_001127510 chr5:g.(112839884_112839885) c.(4291_4290) p.M1431fs RefSeq GRCh38/hg38
NM_001407448.1 chr5:g.(112839830_112839831) c.(4291_4290) p.M1431fs RefSeq GRCh38/hg38
NM_001354896.1 chr5:g.(112839830_112839831) c.(4291_4290) p.M1431fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112839884_112839885) c.(4291_4290) p.M1431fs RefSeq GRCh38/hg38
NM_001407447.1 chr5:g.(112839830_112839831) c.(4291_4290) p.M1431fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112839884_112839885) c.(4291_4290) p.M1431fs RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.(112839884_112839885) c.(4291_4290) p.M1431fs RefSeq GRCh38/hg38
NM_000038 chr5:g.(112839884_112839885) c.(4291_4290) p.M1431fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112839884_112839885) c.(4291_4290) p.M1431fs RefSeq GRCh38/hg38
NM_001407449.1 chr5:g.(112839830_112839831) c.(4291_4290) p.M1431fs RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References