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Gene PTEN
Variant V119del
Impact List deletion
Protein Effect loss of function - predicted
Gene Variant Descriptions PTEN V119del results in the deletion of an amino acid within the phosphatase tensin-type domain of the Pten protein at amino acid 119 (UniProt.org). V119del results in reduced phosphatase activity in a yeast assay (PMID: 29706350), and therefore, is predicted to lead to a loss of Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN V119del

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Transcript NM_000314.8
gDNA chr10:g.87933115_87933117delTTG
cDNA c.356_358delTTG
Protein p.V119delV
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.8 chr10:g.87933115_87933117delTTG c.356_358delTTG p.V119delV RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87933115_87933117delTTG c.356_358delTTG p.V119del RefSeq GRCh38/hg38
NM_001304718.2 chr10:g.87961038_87961040delCTA c.355_357delCTA p.L119delL RefSeq GRCh38/hg38
NM_001304717.5 chr10:g.87864305_87864307delCGC c.355_357delCGC p.R119delR RefSeq GRCh38/hg38

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Molecular Profile Protein Effect Treatment Approaches
PTEN V119del loss of function - predicted Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor PI3K Inhibitor (Pan) PIK3CB inhibitor