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Gene FLT3
Variant C807S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 C807S lies within the protein kinase domain of the Flt3 protein (UniProt.org). C807S does not alter kinase activity or dimerization but results in decreased transformation and phosphorylation of Flt3, Stat5, and Erk in the context of FLT3 internal tandem duplication (FLT3-ITD) in cultured cells (PMID: 31606550), but has not been individually characterized and therefore, its effect on Flt3 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon20 FLT3 C807S

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Transcript NM_004119.3
gDNA chr13:g.28018589A>T
cDNA c.2419T>A
Protein p.C807S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28018589A>T c.2419T>A p.C807S RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28018589A>T c.2419T>A p.C807S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References