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APC N1455fs - Gene Variant Detail

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Gene APC
Variant N1455fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC N1455fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1455 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). N1455fs has not been characterized, however, due to the effects of other truncation mutations downstream of N1455 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC N1455fs

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Transcript NM_000038.6
gDNA chr5:g.(112839956_112839957)
cDNA c.(4363_4362)
Protein p.N1455fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354895.1 chr5:g.(112839956_112839957) c.(4363_4362) p.N1455fs RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.(112839956_112839957) c.(4363_4362) p.N1455fs RefSeq GRCh38/hg38
NM_001354902.2 chr5:g.(112840229_112840230) c.(4363_4362) p.N1455fs RefSeq GRCh38/hg38
NM_000038 chr5:g.(112839956_112839957) c.(4363_4362) p.N1455fs RefSeq GRCh38/hg38
NM_000038.5 chr5:g.(112839956_112839957) c.(4363_4362) p.N1455fs RefSeq GRCh38/hg38
NM_001354902.1 chr5:g.(112840229_112840230) c.(4363_4362) p.N1455fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112839956_112839957) c.(4363_4362) p.N1455fs RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.(112839956_112839957) c.(4363_4362) p.N1455fs RefSeq GRCh38/hg38
NM_001127511.2 chr5:g.(112840010_112840011) c.(4363_4362) p.N1455fs RefSeq GRCh38/hg38
NM_001127510 chr5:g.(112839956_112839957) c.(4363_4362) p.N1455fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112839956_112839957) c.(4363_4362) p.N1455fs RefSeq GRCh38/hg38
NM_001127511 chr5:g.(112840010_112840011) c.(4363_4362) p.N1455fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112839956_112839957) c.(4363_4362) p.N1455fs RefSeq GRCh38/hg38
NM_001127511.3 chr5:g.(112840010_112840011) c.(4363_4362) p.N1455fs RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
APC N1455fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor