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Gene PTEN
Variant V255del
Impact List deletion
Protein Effect loss of function - predicted
Gene Variant Descriptions PTEN V255del results in the deletion of an amino acid in the C2 tensin-type domain of the Pten protein at amino acid 255 (UniProt.org). V255del results in reduced phosphatase activity in a yeast assay (PMID: 29706350), and therefore, is predicted to lead to a loss of Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN V255del

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Transcript NM_000314.8
gDNA chr10:g.87957982_87957984delTAG
cDNA c.764_766delTAG
Protein p.V255delV
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001304717.5 chr10:g.87931080_87931082delAAT c.763_765delAAT p.N255delN RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87957982_87957984delTAG c.764_766delTAG p.V255delV RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87957982_87957984delTAG c.764_766delTAG p.V255del RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
PTEN V255del loss of function - predicted