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PTEN Y188del - Gene Variant Detail

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Gene PTEN
Variant Y188del
Impact List deletion
Protein Effect loss of function - predicted
Gene Variant Descriptions PTEN Y188del results in the deletion of an amino acid of the Pten protein at amino acid 188 (UniProt.org). Y188del results in reduced phosphatase activity in a yeast assay (PMID: 29706350), and therefore, is predicted to lead to a loss of Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN Y188del

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Transcript NM_000314.8
gDNA chr10:g.87952187_87952189delTAT
cDNA c.562_564delTAT
Protein p.Y188delY
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.