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Gene FLT3
Variant C828A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 C828A lies within the protein kinase domain of the Flt3 protein (UniProt.org). C828A does not alter kinase activity in the context of FLT3 internal tandem duplication (FLT3-ITD) in cultured cells (PMID: 31606550), but has not been individually characterized and therefore, its effect on Flt3 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon20 FLT3 C828A

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Transcript NM_004119.3
gDNA chr13:g.28018525_28018526delTGinsGC
cDNA c.2482_2483delTGinsGC
Protein p.C828A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28018525_28018526delTGinsGC c.2482_2483delTGinsGC p.C828A RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28018525_28018526delTGinsGC c.2482_2483delTGinsGC p.C828A RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References