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Gene APC
Variant P1443fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC P1443fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1443 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1443fs has not been characterized, however, due to the effects of other truncation mutations downstream of P1443 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC P1443fs

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Transcript NM_000038.6
gDNA chr5:g.(112839920_112839921)
cDNA c.(4327_4326)
Protein p.P1443fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000038 chr5:g.(112839920_112839921) c.(4327_4326) p.P1443fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112839920_112839921) c.(4327_4326) p.P1443fs RefSeq GRCh38/hg38
NM_000038.5 chr5:g.(112839920_112839921) c.(4327_4326) p.P1443fs RefSeq GRCh38/hg38
NM_001354905.1 chr5:g.(112840400_112840401) c.(4327_4326) p.P1443fs RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.(112839920_112839921) c.(4327_4326) p.P1443fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112839920_112839921) c.(4327_4326) p.P1443fs RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.(112839920_112839921) c.(4327_4326) p.P1443fs RefSeq GRCh38/hg38
NM_001354897.2 chr5:g.(112839890_112839891) c.(4327_4326) p.P1443fs RefSeq GRCh38/hg38
NM_001407455.1 chr5:g.(112840169_112840170) c.(4327_4326) p.P1443fs RefSeq GRCh38/hg38
NM_001407456.1 chr5:g.(112840169_112840170) c.(4327_4326) p.P1443fs RefSeq GRCh38/hg38
NM_001354897.1 chr5:g.(112839890_112839891) c.(4327_4326) p.P1443fs RefSeq GRCh38/hg38
NM_001127510 chr5:g.(112839920_112839921) c.(4327_4326) p.P1443fs RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.(112839920_112839921) c.(4327_4326) p.P1443fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112839920_112839921) c.(4327_4326) p.P1443fs RefSeq GRCh38/hg38
NM_001407454.1 chr5:g.(112840169_112840170) c.(4327_4326) p.P1443fs RefSeq GRCh38/hg38
NM_001407452.1 chr5:g.(112839950_112839951) c.(4327_4326) p.P1443fs RefSeq GRCh38/hg38
NM_001407457.1 chr5:g.(112840169_112840170) c.(4327_4326) p.P1443fs RefSeq GRCh38/hg38
NM_001354905.2 chr5:g.(112840400_112840401) c.(4327_4326) p.P1443fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries