Gene Variant Detail

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Gene FGFR1
Variant M563T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR1 M563T (corresponds to M532T in the canonical isoform) lies within the protein kinase domain of the Fgfr1 protein (UniProt.org). M563T has been identified in the scientific literature (PMID: 34551969), but has not been biochemically characterized and therefore, its effect on Fgfr1 protein function is unknown (PubMed, Oct 2024).
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 M563T

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Transcript NM_001174067.2
gDNA chr8:g.38417374A>G
cDNA c.1688T>C
Protein p.M563T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001174067.2 chr8:g.38417374A>G c.1688T>C p.M563T RefSeq GRCh38/hg38
XM_017013220.2 chr8:g.38417368A>G c.1688T>C p.M563T RefSeq GRCh38/hg38
XM_011544444.2 chr8:g.38417374A>G c.1688T>C p.M563T RefSeq GRCh38/hg38
NM_001174067.1 chr8:g.38417374A>G c.1688T>C p.M563T RefSeq GRCh38/hg38
XM_017013219.2 chr8:g.38417368A>G c.1688T>C p.M563T RefSeq GRCh38/hg38
XM_011544447.3 chr8:g.38417374A>G c.1688T>C p.M563T RefSeq GRCh38/hg38
XM_011544445.3 chr8:g.38417374A>G c.1688T>C p.M563T RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 M563T intrahepatic cholangiocarcinoma predicted - sensitive Futibatinib Case Reports/Case Series Actionable In a Phase I trial, Lytgobi (futibatinib) treatment led to an overall objective response rate of 15.8% (3/19, 3 partial responses) and a disease control rate of 47.4% (9/19), with stable disease in 6, in patients with urothelial cancer harboring an FGFR3 mutation or FGFR1 mutation, including a partial response with a progression-free survival of 6.8 mo and a duration of response of 5.6 mo in a urothelial cancer patient harboring FGFR1 M563T and amplifications in FGF3 and FGF19 (PMID: 34551969; NCT02052778). 34551969