APC Q1367* - Gene Variant Detail

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Gene APC
Variant Q1367*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions APC Q1367* results in a premature truncation of the Apc protein at amino acid 1367 of 2843 (UniProt.org). Q1367* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1367 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC Q1367*

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Transcript NM_000038.6
gDNA chr5:g.112839693C>T
cDNA c.4099C>T
Protein p.Q1367*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407450.1 chr5:g.112839693C>T c.4099C>T p.Q1367* RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112839693C>T c.4099C>T p.Q1367* RefSeq GRCh38/hg38
NM_001407471.1 chr5:g.112840845C>T c.4099C>T p.Q1367* RefSeq GRCh38/hg38
NM_000038 chr5:g.112839693C>T c.4099C>T p.Q1367* RefSeq GRCh38/hg38
NM_001407472.1 chr5:g.112840845C>T c.4099C>T p.Q1367* RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112839693C>T c.4099C>T p.Q1367* RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112839693C>T c.4099C>T p.Q1367* RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112839693C>T c.4099C>T p.Q1367* RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112839693C>T c.4099C>T p.Q1367* RefSeq GRCh38/hg38
NM_001127510 chr5:g.112839693C>T c.4099C>T p.Q1367* RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112839693C>T c.4099C>T p.Q1367* RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC Q1367* colorectal cancer resistant G007-LK Preclinical - Patient cell culture Actionable In a preclinical study, a patient-derived colorectal cancer cell line harboring APC Q1367* was resistant to G007-LK treatment, as demonstrated by failure to inhibit viability in culture (PMID: 37968472). 37968472