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Gene TP53
Variant N239_C242del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions TP53 N239_C242del results in the deletion of four amino acids in the DNA-binding domain of the Tp53 protein from amino acids 239 to 242 (PMID: 22713868, PMID: 38140788). N239_C242del has not been characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 N239_C242del

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Transcript NM_000546.6
gDNA chr17:g.7674237_7674248del12
cDNA c.716_727del12
Protein p.N239_C242delNSSC
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126114.3 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242delNSSC RefSeq GRCh38/hg38
NM_001126115.2 chr17:g.7669669_7669680del12 c.715_726del12 p.S239_G242delSKKG RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242delNSSC RefSeq GRCh38/hg38
NM_001276695.3 chr17:g.7673777_7673788del12 c.716_727del12 p.P239_D242delPGRD RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242delNSSC RefSeq GRCh38/hg38
NM_001407267.1 chr17:g.7673777_7673788del12 c.716_727del12 p.P239_D242delPGRD RefSeq GRCh38/hg38
NM_001407269.1 chr17:g.7673777_7673788del12 c.716_727del12 p.P239_D242delPGRD RefSeq GRCh38/hg38
NM_001276761.3 chr17:g.7673777_7673788del12 c.716_727del12 p.P239_D242delPGRD RefSeq GRCh38/hg38
NM_001407263.1 chr17:g.7673777_7673788del12 c.716_727del12 p.P239_D242delPGRD RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242delNSSC RefSeq GRCh38/hg38
NM_001407265.1 chr17:g.7673777_7673788del12 c.716_727del12 p.P239_D242delPGRD RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242delNSSC RefSeq GRCh38/hg38
NM_001407271.1 chr17:g.7673777_7673788del12 c.716_727del12 p.P239_D242delPGRD RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242del RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242delNSSC RefSeq GRCh38/hg38
NM_001126118.2 chr17:g.7673777_7673788del12 c.716_727del12 p.P239_D242delPGRD RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242del RefSeq GRCh38/hg38
NM_001276696.3 chr17:g.7673777_7673788del12 c.716_727del12 p.P239_D242delPGRD RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242delNSSC RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242delNSSC RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242del RefSeq GRCh38/hg38
NM_001276760.3 chr17:g.7673777_7673788del12 c.716_727del12 p.P239_D242delPGRD RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242del RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242delNSSC RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References