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Gene DNMT3A
Variant W601*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions DNMT3A W601* results in a premature truncation of the Dnmt3a protein at amino acid 601 of 912 (UniProt.org). W601* has not been characterized, however, due to the effects of other truncation mutations downstream of W601 (PMID: 28872462, PMID: 26595813, PMID: 35639959), is predicted to lead to a loss of Dnmt3a protein function.
Associated Drug Resistance
Category Variants Paths

DNMT3A mutant DNMT3A inact mut DNMT3A W601*

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Transcript NM_022552.5
gDNA chr2:g.25244204C>T
cDNA c.1802G>A
Protein p.W601*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_175629.2 chr2:g.25244204C>T c.1802G>A p.W601* RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25244204C>T c.1802G>A p.W601* RefSeq GRCh38/hg38
XM_011532664.3 chr2:g.25244204C>T c.1802G>A p.W601* RefSeq GRCh38/hg38
XM_047443593.1 chr2:g.25244204C>T c.1802G>A p.W601* RefSeq GRCh38/hg38
NM_022552.4 chr2:g.25244204C>T c.1802G>A p.W601* RefSeq GRCh38/hg38
XM_005264175.5 chr2:g.25244204C>T c.1802G>A p.W601* RefSeq GRCh38/hg38
XM_011532664.2 chr2:g.25244204C>T c.1802G>A p.W601* RefSeq GRCh38/hg38
XM_017003526.2 chr2:g.25244204C>T c.1802G>A p.W601* RefSeq GRCh38/hg38
XM_005264175.6 chr2:g.25244204C>T c.1802G>A p.W601* RefSeq GRCh38/hg38
NM_001320893.1 chr2:g.25240366C>T c.1802G>A p.W601* RefSeq GRCh38/hg38
XM_017003526.1 chr2:g.25244204C>T c.1802G>A p.W601* RefSeq GRCh38/hg38
NM_022552.5 chr2:g.25244204C>T c.1802G>A p.W601* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
DNMT3A W601* loss of function - predicted