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Gene APC
Variant K1310fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC K1310fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1310 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). K1310fs has not been characterized, however, due to the effects of other truncation mutations downstream of K1310 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC K1310fs

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Transcript NM_000038.6
gDNA chr5:g.(112839521_112839522)
cDNA c.(3928_3927)
Protein p.K1310fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354895.2 chr5:g.(112839521_112839522) c.(3928_3927) p.K1310fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112839521_112839522) c.(3928_3927) p.K1310fs RefSeq GRCh38/hg38
NM_001354906.2 chr5:g.(112840370_112840371) c.(3928_3927) p.K1310fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112839521_112839522) c.(3928_3927) p.K1310fs RefSeq GRCh38/hg38
NM_001354906.1 chr5:g.(112840370_112840371) c.(3928_3927) p.K1310fs RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.(112839521_112839522) c.(3928_3927) p.K1310fs RefSeq GRCh38/hg38
NM_000038 chr5:g.(112839521_112839522) c.(3928_3927) p.K1310fs RefSeq GRCh38/hg38
NM_000038.5 chr5:g.(112839521_112839522) c.(3928_3927) p.K1310fs RefSeq GRCh38/hg38
NM_001127510 chr5:g.(112839521_112839522) c.(3928_3927) p.K1310fs RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.(112839521_112839522) c.(3928_3927) p.K1310fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112839521_112839522) c.(3928_3927) p.K1310fs RefSeq GRCh38/hg38
NM_001407470.1 chr5:g.(112840370_112840371) c.(3928_3927) p.K1310fs RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries