FLT3 E778K
Gene Variant Detail

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Gene FLT3
Variant E778K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 E778K lies within the protein kinase domain of the Flt3 protein (UniProt.org). E778K has been identified in the scientific literature (PMID: 32040554), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Jun 2025).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon19 FLT3 E778K

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Transcript NM_004119.3
gDNA chr13:g.28023436C>T
cDNA c.2332G>A
Protein p.E778K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28023436C>T c.2332G>A p.E778K RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28023436C>T c.2332G>A p.E778K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References