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Gene FLT3
Variant G846D
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FLT3 G846D lies within the protein kinase domain of the Flt3 protein (UniProt.org). G846D confers a gain of function to Flt3 as demonstrated by IL3-independent growth and increased Stat5 phosphorylation in cultured cells (PMID: 38049555).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 G846D

FLT3 mutant FLT3 exon20 FLT3 G846D

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Transcript NM_004119.3
gDNA chr13:g.28018471C>T
cDNA c.2537G>A
Protein p.G846D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28018471C>T c.2537G>A p.G846D RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28018471C>T c.2537G>A p.G846D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 G846D hematologic cancer sensitive Midostaurin Preclinical - Cell culture Actionable In a preclinical study, Rydapt (midostaurin) inhibited growth of cells expressing FLT3 G846D in culture (PMID: 38049555). 38049555
FLT3 G846D hematologic cancer resistant Sorafenib Preclinical - Cell culture Actionable In a preclinical study, a cell line expressing FLT3 G846D was resistant to Nexavar (sorafenib) in culture (PMID: 38049555). 38049555