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Gene TP53
Variant T155fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 T155fs results in a change in the amino acid sequence of the Tp53 protein beginning at aa 155 of 393, likely resulting in premature truncation of the functional protein (UniProt.org). T155fs has not been biochemically characterized however, due to the effects of truncation mutations downstream of T155 (PMID: 31081129, PMID: 34045312), is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 T155fs

TP53 mutant TP53 inact mut TP53 T155fs

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Transcript NM_000546.6
gDNA chr17:g.(7675149_7675150)
cDNA c.(463_462)
Protein p.T155fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407264.1 chr17:g.(7675149_7675150) c.(463_462) p.T155fs RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.(7675149_7675150) c.(463_462) p.T155fs RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.(7675149_7675150) c.(463_462) p.T155fs RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.(7675149_7675150) c.(463_462) p.T155fs RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.(7675149_7675150) c.(463_462) p.T155fs RefSeq GRCh38/hg38
NM_000546.6 chr17:g.(7675149_7675150) c.(463_462) p.T155fs RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.(7675149_7675150) c.(463_462) p.T155fs RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.(7675149_7675150) c.(463_462) p.T155fs RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.(7675149_7675150) c.(463_462) p.T155fs RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.(7675149_7675150) c.(463_462) p.T155fs RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.(7675149_7675150) c.(463_462) p.T155fs RefSeq GRCh38/hg38
NM_000546.5 chr17:g.(7675149_7675150) c.(463_462) p.T155fs RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.(7675149_7675150) c.(463_462) p.T155fs RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
TP53 T155fs loss of function - predicted p53 Gene Therapy