PALB2 R153W
Gene Variant Detail

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Gene PALB2
Variant R153W
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions PALB2 R153W lies within the DNA-binding, and BRCA1 and RAD51-interacting regions of the Palb2 protein (UniProt.org). R153W results in homology-directed DNA repair activity similar to wild-type Palb2 in cultured cells (PMID: 35853885), and therefore, is predicted to have no effect on Palb2 protein function.
Associated Drug Resistance
Category Variants Paths

PALB2 mutant PALB2 R153W

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Transcript NM_024675.4
gDNA chr16:g.23636089T>A
cDNA c.457A>T
Protein p.R153W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017023673.2 chr16:g.23636089T>A c.457A>T p.R153W RefSeq GRCh38/hg38
NM_001407314.1 chr16:g.23623042T>A c.457A>T p.R153W RefSeq GRCh38/hg38
NM_001407300.1 chr16:g.23636089T>A c.457A>T p.R153W RefSeq GRCh38/hg38
NM_001407301.1 chr16:g.23636089T>A c.457A>T p.R153W RefSeq GRCh38/hg38
NM_001407299.1 chr16:g.23636089T>A c.457A>T p.R153W RefSeq GRCh38/hg38
NM_001407297.1 chr16:g.23636089T>A c.457A>T p.R153W RefSeq GRCh38/hg38
NM_001407298.1 chr16:g.23636089T>A c.457A>T p.R153W RefSeq GRCh38/hg38
NM_024675.4 chr16:g.23636089T>A c.457A>T p.R153W RefSeq GRCh38/hg38
NM_001407302.1 chr16:g.23636089T>A c.457A>T p.R153W RefSeq GRCh38/hg38
XM_017023672.2 chr16:g.23636089T>A c.457A>T p.R153W RefSeq GRCh38/hg38
NM_024675.3 chr16:g.23636089T>A c.457A>T p.R153W RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
PALB2 R153W no effect - predicted