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Gene FLT3
Variant K663Q
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FLT3 K663Q lies within the protein kinase domain of the Flt3 protein (UniProt.org). K663Q results in constitutive phosphorylation of Flt3 and activation of Akt, Mapk, and Stat pathways in cell culture (PMID: 16990784), and therefore, is predicted to lead to a gain of Flt3 protein function.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 K663Q

FLT3 mutant FLT3 exon16 FLT3 K663Q

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Transcript NM_004119.3
gDNA chr13:g.28028244T>G
cDNA c.1987A>C
Protein p.K663Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28028244T>G c.1987A>C p.K663Q RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28028244T>G c.1987A>C p.K663Q RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FLT3 K663Q gain of function - predicted FLT3 Inhibitor