APC S1355P
Gene Variant Detail

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Gene APC
Variant S1355P
Impact List missense
Protein Effect unknown
Gene Variant Descriptions APC S1355P lies within the beta-catenin binding and downregulation region of the Apc protein (PMID: 14672538). S1355P has been identified in sequencing studies (PMID: 17558858, PMID: 29523763, PMID: 28222664), but has not been biochemically characterized and therefore, its effect on Apc protein function is unknown (PubMed, Sep 2025).
Associated Drug Resistance
Category Variants Paths

APC mutant APC S1355P

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Transcript NM_000038.6
gDNA chr5:g.112839657T>C
cDNA c.4063T>C
Protein p.S1355P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001127510 chr5:g.112839657T>C c.4063T>C p.S1355P RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112839657T>C c.4063T>C p.S1355P RefSeq GRCh38/hg38
NM_001407451.1 chr5:g.112839678T>C c.4063T>C p.S1355P RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112839657T>C c.4063T>C p.S1355P RefSeq GRCh38/hg38
NM_001407446.1 chr5:g.112839573T>C c.4063T>C p.S1355P RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112839657T>C c.4063T>C p.S1355P RefSeq GRCh38/hg38
NM_000038 chr5:g.112839657T>C c.4063T>C p.S1355P RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112839657T>C c.4063T>C p.S1355P RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112839657T>C c.4063T>C p.S1355P RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112839657T>C c.4063T>C p.S1355P RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112839657T>C c.4063T>C p.S1355P RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
APC S1355P unknown