APC S1356*
Gene Variant Detail

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Gene APC
Variant S1356*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions APC S1356* results in a premature truncation of the Apc protein at amino acid 1356 of 2843 (UniProt.org). S1356* has not been characterized, however, due to the effects of other truncation mutations downstream of S1356 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC S1356*

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Transcript NM_000038.6
gDNA chr5:g.112839661C>A
cDNA c.4067C>A
Protein p.S1356*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407453.1 chr5:g.112839837_112839839delAGTinsTGA c.4066_4068delAGTinsTGA p.S1356* RefSeq GRCh38/hg38
NM_001127510 chr5:g.112839661C>A c.4067C>A p.S1356* RefSeq GRCh38/hg38
NM_001354901.2 chr5:g.112839837_112839839delAGTinsTGA c.4066_4068delAGTinsTGA p.S1356* RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112839661C>A c.4067C>A p.S1356* RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112839661C>A c.4067C>A p.S1356* RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112839661C>A c.4067C>A p.S1356* RefSeq GRCh38/hg38
NM_000038 chr5:g.112839661C>A c.4067C>A p.S1356* RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112839661C>A c.4067C>A p.S1356* RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112839661C>A c.4067C>A p.S1356* RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112839661C>A c.4067C>A p.S1356* RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112839661C>A c.4067C>A p.S1356* RefSeq GRCh38/hg38
NM_001354897.1 chr5:g.112839631C>A c.4067C>A p.S1356* RefSeq GRCh38/hg38
NM_001354901.1 chr5:g.112839837_112839839delAGTinsTGA c.4066_4068delAGTinsTGA p.S1356* RefSeq GRCh38/hg38
NM_001354897.2 chr5:g.112839631C>A c.4067C>A p.S1356* RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC S1356* colorectal cancer sensitive G007-LK Preclinical - Patient cell culture Actionable In a preclinical study, G007-LK inhibited viability of a patient-derived colorectal cancer cell line harboring APC S1356* in culture (PMID: 37968472). 37968472